Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus
Joint Authors
Zhou, Lei
Su, Jing
Li, Xiaoning
Yang, Xiaochun
Zhang, Yu
Kong, Xiaoxia
Xiang, Xi-yan
Sun, Lian-kun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide.
The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis.
The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis.
Therefore, the ER is one site of interaction between environmental signals and a cell’s biological function.
The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications.
Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM.
Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease.
American Psychological Association (APA)
Su, Jing& Zhou, Lei& Kong, Xiaoxia& Yang, Xiaochun& Xiang, Xi-yan& Zhang, Yu…[et al.]. 2013. Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453416
Modern Language Association (MLA)
Su, Jing…[et al.]. Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus. Journal of Diabetes Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453416
American Medical Association (AMA)
Su, Jing& Zhou, Lei& Kong, Xiaoxia& Yang, Xiaochun& Xiang, Xi-yan& Zhang, Yu…[et al.]. Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453416