Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model
Joint Authors
Forgiarini, Luiz Felipe
Forgiarini Junior, Luiz Alberto
Cardoso, Paulo Francisco Guerreiro
Andrade, Cristiano Feijó
Holand, Arthur Rodrigo Ronconi
da Rosa, Darlan Pase
Marroni, Norma Anair Possa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study was to evaluate the use of liquid perfluorocarbon (PFC) as an adjuvant substance for lung preservation and assess its role in pulmonary protection after transplantation.
Methods.
Seventy-two rat lungs were flushed with low-potassium dextran (LPD) solution and randomized into three main groups: control with LPD alone and experimental with 3 (PFC3) and 7 mL/kg (PFC7) of endobronchial PFC instilled just after harvest.
Each group was divided into four subgroups according to preservation time (3, 6, 12, and 24 hours).
Afterwards, we performed lung transplantation using rat lungs preserved for 12 hours with LPD alone or with 7 mL/kg of endobronchial PFC.
Results.
There was a significant increase in oxidative stress in the control group at 6 h of cold ischemic time compared with the PFC3 and PFC7 groups.
The apoptotic activity and NF-κB expression were significantly higher in the control group compared with the PFC groups at 3, 12, and 24 h of cold preservation.
After transplantation, the NF-κB, iNOS, and nitrotyrosine expression as well as caspase 3 activity were significantly lower in the PFC groups.
Conclusion.
The use of endobronchial PFC as an adjuvant to the current preservation strategy improved graft viability.
American Psychological Association (APA)
Forgiarini Junior, Luiz Alberto& Holand, Arthur Rodrigo Ronconi& Forgiarini, Luiz Felipe& da Rosa, Darlan Pase& Marroni, Norma Anair Possa& Cardoso, Paulo Francisco Guerreiro…[et al.]. 2013. Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453417
Modern Language Association (MLA)
Forgiarini Junior, Luiz Alberto…[et al.]. Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-453417
American Medical Association (AMA)
Forgiarini Junior, Luiz Alberto& Holand, Arthur Rodrigo Ronconi& Forgiarini, Luiz Felipe& da Rosa, Darlan Pase& Marroni, Norma Anair Possa& Cardoso, Paulo Francisco Guerreiro…[et al.]. Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453417