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The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
Joint Authors
Yasuda, Mako
Maegawa, Hiroshi
Uzu, Takashi
Kume, Shinji
Koya, Daisuke
Yamahara, Kosuke
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic nephropathy is a leading cause of end-stage renal disease worldwide.
The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy.
Therefore, a new therapeutic target to combat diabetic nephropathy is required.
Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis.
The accumulation of proteins and organelles damaged by hyperglycemia and other diabetes-related metabolic changes is highly associated with the development of diabetic nephropathy.
Recent studies have suggested that autophagy activity is altered in both podocytes and proximal tubular cells under diabetic conditions.
Autophagy activity is regulated by both nutrient state and intracellular stresses.
Under diabetic conditions, an altered nutritional state due to nutrient excess may interfere with the autophagic response stimulated by intracellular stresses, leading to exacerbation of organelle dysfunction and diabetic nephropathy.
In this review, we discuss new findings showing the relationships between autophagy and diabetic nephropathy and suggest the therapeutic potential of autophagy in diabetic nephropathy.
American Psychological Association (APA)
Yamahara, Kosuke& Yasuda, Mako& Kume, Shinji& Koya, Daisuke& Maegawa, Hiroshi& Uzu, Takashi. 2013. The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453450
Modern Language Association (MLA)
Yamahara, Kosuke…[et al.]. The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-453450
American Medical Association (AMA)
Yamahara, Kosuke& Yasuda, Mako& Kume, Shinji& Koya, Daisuke& Maegawa, Hiroshi& Uzu, Takashi. The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453450