Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer
Joint Authors
Huang, Chi-Ying F.
Lin, Yong-Jie
Chang, Peter Mu-Hsin
Huang, Chien-Hung
Wang, Cheng-Hsu
Ng, Ka-Lok
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Drug repositioning is a popular approach in the pharmaceutical industry for identifying potential new uses for existing drugs and accelerating the development time.
Non-small-cell lung cancer (NSCLC) is one of the leading causes of death worldwide.
To reduce the biological heterogeneity effects among different individuals, both normal and cancer tissues were taken from the same patient, hence allowing pairwise testing.
By comparing early- and late-stage cancer patients, we can identify stage-specific NSCLC genes.
Differentially expressed genes are clustered separately to form up- and downregulated communities that are used as queries to perform enrichment analysis.
The results suggest that pathways for early- and late-stage cancers are different.
Sets of up- and downregulated genes were submitted to the cMap web resource to identify potential drugs.
To achieve high confidence drug prediction, multiple microarray experimental results were merged by performing meta-analysis.
The results of a few drug findings are supported by MTT assay or clonogenic assay data.
In conclusion, we have been able to assess the potential existing drugs to identify novel anticancer drugs, which may be helpful in drug repositioning discovery for NSCLC.
American Psychological Association (APA)
Huang, Chien-Hung& Chang, Peter Mu-Hsin& Lin, Yong-Jie& Wang, Cheng-Hsu& Huang, Chi-Ying F.& Ng, Ka-Lok. 2014. Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453458
Modern Language Association (MLA)
Huang, Chien-Hung…[et al.]. Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-453458
American Medical Association (AMA)
Huang, Chien-Hung& Chang, Peter Mu-Hsin& Lin, Yong-Jie& Wang, Cheng-Hsu& Huang, Chi-Ying F.& Ng, Ka-Lok. Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453458