Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation
Joint Authors
Ye, Fengchun
Gao, Shou-Jiang
Lei, Xiufen
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-09
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of latent and lytic replication phases.
During latent infection, only a limited number of KSHV genes are expressed.
However, this phase of replication is essential for persistent infection, evasion of host immune response, and induction of KSHV-related malignancies.
KSHV reactivation from latency produces a wide range of viral products and infectious virions.
The resulting de novo infection and viral lytic products modulate diverse cellular pathways and stromal microenvironment, which promote the development of Kaposi's sarcoma (KS).
The mechanisms controlling KSHV latency and reactivation are complex, involving both viral and host factors, and are modulated by diverse environmental factors.
Here, we review the cellular and molecular basis of KSHV latency and reactivation with a focus on the most recent advancements in the field.
American Psychological Association (APA)
Ye, Fengchun& Lei, Xiufen& Gao, Shou-Jiang. 2011. Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. Advances in Virology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-453462
Modern Language Association (MLA)
Ye, Fengchun…[et al.]. Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. Advances in Virology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-453462
American Medical Association (AMA)
Ye, Fengchun& Lei, Xiufen& Gao, Shou-Jiang. Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-453462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453462