Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice
Joint Authors
González-González, G.
Perez-Tapia, S. M.
Limón-Flores, A.
Pavon, L.
Robledo-Ávila, F.
Wong-Baeza, Isabel
Estrada-Parra, Sergio
Estrada-Garcia, Iris
Tovar, C.
Hernández-Pando, Rogelio
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Candida albicans causes opportunistic systemic infections with high mortality (30%–50%).
Despite significant nephrotoxicity, amphotericin (AmB) is still used for the treatment of this serious fungal infection.
Therefore, alternative treatments are urgently needed.
Dialyzable leukocyte extracts have been used successfully to treat patients with mucocutaneous candidiasis, but their effectiveness in systemic candidiasis has not been evaluated.
In this study, low-dose AmB (0.1 mg/kg) plus 10 pg of murine dialyzable spleen extracts (mDSE) were tested in a systemic candidiasis mouse model.
Survival, tissue fungal burden, kidney damage, kidney cytokines, and serum levels of IL-6 and hepcidin were evaluated.
Our results showed that the combined treatment of low-dose AmB plus mDSE improved survival and reduced kidney fungal burden and histopathology; these effects correlated with increased kidney concentration of IFN-γ and TGF-β1, decreased levels of TNF-α, IL-6, and IL-10, as well as high levels of systemic IL-6 and hepcidin.
Low-dose AmB and mDSE synergized to clear the infectious agent and reduced tissue damage, confirming the efficacy of a low dose of AmB, which might decrease the risk of drug toxicity.
Further studies are necessary to explore these findings and its implications in future therapeutic approaches.
American Psychological Association (APA)
Robledo-Ávila, F.& Perez-Tapia, S. M.& Limón-Flores, A.& Pavon, L.& Hernández-Pando, Rogelio& Wong-Baeza, Isabel…[et al.]. 2013. Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453479
Modern Language Association (MLA)
Robledo-Ávila, F.…[et al.]. Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-453479
American Medical Association (AMA)
Robledo-Ávila, F.& Perez-Tapia, S. M.& Limón-Flores, A.& Pavon, L.& Hernández-Pando, Rogelio& Wong-Baeza, Isabel…[et al.]. Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453479