![](/images/graphics-bg.png)
Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?
Joint Authors
Soares-Sobrinho, J. L.
De Lucca Junior, W.
Soares, M. F. R.
Mendonça Junior, F. J. B.
de Almeida, Antonia Amanda Cardoso
Santos, P. S.
de Freitas, Rivelilson Mendes
Fortes, A. C.
de Oliveira, Guilherme Antônio Lopes
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, 5TIO1, is a new 2-aminothiophene derivative with promising pharmacological activities.
The aim of this study was to evaluate its antioxidant activity in different areas of mice central nervous system.
Male Swiss adult mice were intraperitoneally treated with Tween 80 dissolved in 0.9% saline (control group) and 5TIO1 (0.1, 1, and 10 mg kg−1).
Brain homogenates—hippocampus, striatum, frontal cortex, and cerebellum—were obtained after 24 h of observation.
Superoxide dismutase and catalase activities, lipid peroxidation and nitrite content were measured using spectrophotometrical methods.
To clarify the 5TIO1’s mechanism on oxidative stress, western blot analysis of superoxide dismutase and catalase was also performed.
5TIO1 decreased lipid peroxidation and nitrite content in all brain areas and increased the antioxidant enzymatic activities, specially, in cerebellum.
The data of Western blot analysis did not demonstrate evidence of the upregulation of these enzymes after the administration of this compound.
Our findings strongly support that 5TIO1 can protect the brain against neuronal damages regularly observed during neuropathologies.
American Psychological Association (APA)
Fortes, A. C.& de Almeida, Antonia Amanda Cardoso& de Oliveira, Guilherme Antônio Lopes& Santos, P. S.& De Lucca Junior, W.& Mendonça Junior, F. J. B.…[et al.]. 2013. Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453491
Modern Language Association (MLA)
Fortes, A. C.…[et al.]. Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-453491
American Medical Association (AMA)
Fortes, A. C.& de Almeida, Antonia Amanda Cardoso& de Oliveira, Guilherme Antônio Lopes& Santos, P. S.& De Lucca Junior, W.& Mendonça Junior, F. J. B.…[et al.]. Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453491