A Two-Stage Joint Model for Nonlinear Longitudinal Response and a Time-to-Event with Application in Transplantation Studies
Joint Authors
Rizopoulos, Dimitris
Lesaffre, Emmanuel
Murawska, Magdalena
Source
Journal of Probability and Statistics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
In transplantation studies, often longitudinal measurements are collected for important markers prior to the actual transplantation.
Using only the last available measurement as a baseline covariate in a survival model for the time to graft failure discards the whole longitudinal evolution.
We propose a two-stage approach to handle this type of data sets using all available information.
At the first stage, we summarize the longitudinal information with nonlinear mixed-effects model, and at the second stage, we include the Empirical Bayes estimates of the subject-specific parameters as predictors in the Cox model for the time to allograft failure.
To take into account that the estimated subject-specific parameters are included in the model, we use a Monte Carlo approach and sample from the posterior distribution of the random effects given the observed data.
Our proposal is exemplified on a study of the impact of renal resistance evolution on the graft survival.
American Psychological Association (APA)
Murawska, Magdalena& Rizopoulos, Dimitris& Lesaffre, Emmanuel. 2012. A Two-Stage Joint Model for Nonlinear Longitudinal Response and a Time-to-Event with Application in Transplantation Studies. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-453492
Modern Language Association (MLA)
Murawska, Magdalena…[et al.]. A Two-Stage Joint Model for Nonlinear Longitudinal Response and a Time-to-Event with Application in Transplantation Studies. Journal of Probability and Statistics No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-453492
American Medical Association (AMA)
Murawska, Magdalena& Rizopoulos, Dimitris& Lesaffre, Emmanuel. A Two-Stage Joint Model for Nonlinear Longitudinal Response and a Time-to-Event with Application in Transplantation Studies. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-453492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453492