Comparison of RiboflavinUltraviolet-A Cross-Linking in Porcine, Rabbit, and Human Sclera
Joint Authors
Han, Xuguang
Mu, Guoying
Zhang, Yali
Li, Zhiwei
Zhao, Xiaomin
Liu, Lei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To compare the biomechanical properties of porcine, rabbit, and human sclera before and after riboflavin/ultraviolet-A (UVA) collagen cross-linking (CXL).
Methods.
Eight rabbits, 8 porcine eyeballs, and 8 human eyeballs were included.
One rabbit eye and half of each bisected human and porcine eyeball were treated with riboflavin/UVA CXL.
Untreated fellow rabbit eyes and eyeball halves served as controls.
A 10 mm × 20 mm scleral band was harvested from each specimen.
From this band, two 3.5 mm × 15.0 mm strips were prepared for biomechanical testing.
The biomechanical parameters were ultimate stress, stress and Young’s modulus.
Results.
Values of stress, and Young’s modulus showed that human sclera was 4 times stiffer than porcine sclera and 3 times stiffer than rabbit sclera.
In rabbit sclera, both the stress and Young’s modulus were significantly increased by CXL (P<0.05).
In porcine sclera, only the ultimate stress was significantly increased by CXL (P<0.05).
The biomechanical properties of human sclera were not statistically affected by CXL (P>0.05).
Conclusions.
Human sclera has higher biomechanical stiffness than porcine and rabbit sclera.
With the same irradiation dose, riboflavin/UVA CXL increases the biomechanical stiffness of rabbit sclera but not porcine or human sclera.
American Psychological Association (APA)
Zhang, Yali& Li, Zhiwei& Liu, Lei& Han, Xuguang& Zhao, Xiaomin& Mu, Guoying. 2014. Comparison of RiboflavinUltraviolet-A Cross-Linking in Porcine, Rabbit, and Human Sclera. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-453494
Modern Language Association (MLA)
Zhang, Yali…[et al.]. Comparison of RiboflavinUltraviolet-A Cross-Linking in Porcine, Rabbit, and Human Sclera. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-453494
American Medical Association (AMA)
Zhang, Yali& Li, Zhiwei& Liu, Lei& Han, Xuguang& Zhao, Xiaomin& Mu, Guoying. Comparison of RiboflavinUltraviolet-A Cross-Linking in Porcine, Rabbit, and Human Sclera. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-453494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453494