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Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases : A Mitochondrial Issue
Joint Authors
Rodríguez, Manuel J.
Ortega, Francisco J.
Mahy, Nicole
Martínez-Moreno, Margot
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Neurodegeneration is a complex process involving different cell types and neurotransmitters.
A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in response to neuronal death.
Microglia do not constitute a unique cell population but rather present a range of phenotypes closely related to the evolution of neurodegeneration.
In a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling.
At each moment, the microglial phenotype is likely to depend on the diversity of signals from the environment and of its response capacity.
As a consequence, microglia present a high energy demand, for which the mitochondria activity determines the microglia participation in the neurodegenerative process.
As such, modulation of microglia activity by controlling microglia mitochondrial activity constitutes an innovative approach to interfere in the neurodegenerative process.
In this review, we discuss the mitochondrial KATP channel as a new target to control microglia activity, avoid its toxic phenotype, and facilitate a positive disease outcome.
American Psychological Association (APA)
Rodríguez, Manuel J.& Martínez-Moreno, Margot& Ortega, Francisco J.& Mahy, Nicole. 2013. Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases : A Mitochondrial Issue. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-453520
Modern Language Association (MLA)
Rodríguez, Manuel J.…[et al.]. Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases : A Mitochondrial Issue. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-453520
American Medical Association (AMA)
Rodríguez, Manuel J.& Martínez-Moreno, Margot& Ortega, Francisco J.& Mahy, Nicole. Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases : A Mitochondrial Issue. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-453520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453520