Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model
Joint Authors
Omer, Sawsan A.
ElAmin, Maha
Elobeid, Mai A.
Virk, Promy
Hassan, Zeinab K.
AlOlayan, Ebtisam M.
Daghestani, Maha H.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage.
Bisphenol A (BPA) is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells.
Due to limited information concerning the effect of BPA on liver, this study investigates whether BPA causes hepatotoxicity by induction of oxidative stress in liver.
Rats were divided into five groups: The first four groups, BPA (0.1, 1, 10, 50 mg/kg/day) were administrated orally to rats for four weeks.
The fifth group was taken water with vehicle.
The final body weights in the 0.1 mg group showed a significant decrease compared to control group.
Significant decreased levels of reduced glutathione, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase activity were found in the 50 mg BPA group compared to control groups.
High dose of BPA (50 mg/kg) significantly increased the biochemical levels of ALT, ALP and total bilirubin.
BPA effect on the activity of antioxidant genes was confirmed by real time PCR in which the expression levels of these genes in liver tissue were significantly decrease compared to control.
Data from this study demonstrate that BPA generate ROS and reduce the antioxidant gene expression that causes hepatotoxicity.
American Psychological Association (APA)
Hassan, Zeinab K.& Elobeid, Mai A.& Virk, Promy& Omer, Sawsan A.& ElAmin, Maha& Daghestani, Maha H.…[et al.]. 2012. Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453549
Modern Language Association (MLA)
Hassan, Zeinab K.…[et al.]. Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-453549
American Medical Association (AMA)
Hassan, Zeinab K.& Elobeid, Mai A.& Virk, Promy& Omer, Sawsan A.& ElAmin, Maha& Daghestani, Maha H.…[et al.]. Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453549