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Mesenchymal Stem Cell Therapy in Diabetes Mellitus : Progress and Challenges
Joint Authors
Ghoneim, Mohamed A.
El-Badri, Nagwa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Advanced type 2 diabetes mellitus is associated with significant morbidity and mortality due to cardiovascular, nervous, and renal complications.
Attempts to cure diabetes mellitus using islet transplantation have been successful in providing a source for insulin secreting cells.
However, limited donors, graft rejection, the need for continued immune suppression, and exhaustion of the donor cell pool prompted the search for a more sustained source of insulin secreting cells.
Stem cell therapy is a promising alternative for islet transplantation in type 2 diabetic patients who fail to control hyperglycemia even with insulin injection.
Autologous stem cell transplantation may provide the best outcome for those patients, since autologous cells are readily available and do not entail prolonged hospital stays or sustained immunotoxic therapy.
Among autologous adult stem cells, mesenchymal stem cells (MSCs) therapy has been applied with varying degrees of success in both animal models and in clinical trials.
This review will focus on the advantages of MSCs over other types of stem cells and the possible mechanisms by which MSCs transplant restores normoglycemia in type 2 diabetic patients.
Sources of MSCs including autologous cells from diabetic patients and the use of various differentiation protocols in relation to best transplant outcome will be discussed.
American Psychological Association (APA)
El-Badri, Nagwa& Ghoneim, Mohamed A.. 2013. Mesenchymal Stem Cell Therapy in Diabetes Mellitus : Progress and Challenges. Journal of Nucleic Acids،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453555
Modern Language Association (MLA)
El-Badri, Nagwa& Ghoneim, Mohamed A.. Mesenchymal Stem Cell Therapy in Diabetes Mellitus : Progress and Challenges. Journal of Nucleic Acids No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-453555
American Medical Association (AMA)
El-Badri, Nagwa& Ghoneim, Mohamed A.. Mesenchymal Stem Cell Therapy in Diabetes Mellitus : Progress and Challenges. Journal of Nucleic Acids. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453555