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The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification
Joint Authors
Carey, P.
Beetge, E.
Rubow, S.
Warwick, J. M.
du Toit, M.
Dupont, P.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Striatal single photon emission computed tomography (SPECT) imaging of the dopaminergic system is becoming increasingly used for clinical and research studies.
The question about the value of nonuniform attenuation correction has become more relevant with the increasing availability of hybrid SPECT-CT scanners.
In this study, the value of nonuniform attenuation correction and correction for collimator blurring were determined using both phantom data and patient data.
Methods.
SPECT imaging was performed using 7 anthropomorphic phantom measurements, and 14 patient studies using [I-123]-FP-CIT (DATSCAN).
SPECT reconstruction was performed using uniform and nonuniform attenuation correction and collimator blurring corrections.
Recovery values (phantom data) or average-specific uptake ratios (patient data) for the different reconstructions were compared at similar noise levels.
Results.
For the phantom data, improved recovery was found with nonuniform attenuation correction and collimator blurring corrections, with further improvement when performed together.
However, for patient data the highest average specific uptake ratio was obtained using collimator blurring correction without nonuniform attenuation correction, probably due to subtle SPECT-CT misregistration.
Conclusions.
This study suggests that an optimal brain SPECT reconstruction (in terms of the lowest bias) in patients would include a correction for collimator blurring and uniform attenuation correction.
American Psychological Association (APA)
Warwick, J. M.& Rubow, S.& du Toit, M.& Beetge, E.& Carey, P.& Dupont, P.. 2011. The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453569
Modern Language Association (MLA)
Warwick, J. M.…[et al.]. The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification. International Journal of Molecular Imaging No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-453569
American Medical Association (AMA)
Warwick, J. M.& Rubow, S.& du Toit, M.& Beetge, E.& Carey, P.& Dupont, P.. The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453569