Structural Insight into the DNA-Binding Mode of the Primosomal Proteins PriA, PriB, and DnaT
Joint Authors
Huang, Cheng-Yang
Huang, Yen-Hua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Replication restart primosome is a complex dynamic system that is essential for bacterial survival.
This system uses various proteins to reinitiate chromosomal DNA replication to maintain genetic integrity after DNA damage.
The replication restart primosome in Escherichia coli is composed of PriA helicase, PriB, PriC, DnaT, DnaC, DnaB helicase, and DnaG primase.
The assembly of the protein complexes within the forked DNA responsible for reloading the replicative DnaB helicase anywhere on the chromosome for genome duplication requires the coordination of transient biomolecular interactions.
Over the last decade, investigations on the structure and mechanism of these nucleoproteins have provided considerable insight into primosome assembly.
In this review, we summarize and discuss our current knowledge and recent advances on the DNA-binding mode of the primosomal proteins PriA, PriB, and DnaT.
American Psychological Association (APA)
Huang, Yen-Hua& Huang, Cheng-Yang. 2014. Structural Insight into the DNA-Binding Mode of the Primosomal Proteins PriA, PriB, and DnaT. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-453583
Modern Language Association (MLA)
Huang, Yen-Hua& Huang, Cheng-Yang. Structural Insight into the DNA-Binding Mode of the Primosomal Proteins PriA, PriB, and DnaT. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-453583
American Medical Association (AMA)
Huang, Yen-Hua& Huang, Cheng-Yang. Structural Insight into the DNA-Binding Mode of the Primosomal Proteins PriA, PriB, and DnaT. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-453583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453583