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The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-Cell Lymphoma
Joint Authors
Coaccioli, Stefano
Emili, Rita
Gunnellini, Marco
Liberati, Anna Marina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL) accounting for approximately 30% of new lymphoma diagnoses in adult patients.
Complete remissions (CRs) can be achieved in 45% to 55% of patients and cure in approximately 30–35% with anthracycline-containing combination chemotherapy.
The ageadjusted IPI (aaIPI) has been widely employed, particularly to “tailor” more intensive therapy such as high-dose therapy (HDT) with autologous hemopoietic stem cell rescue (ASCT).
IPI, however, has failed to reliably predict response to specific therapies.
A subgroup of young patients with poor prognosis exists.
To clarify the role of HDT/ASCT combined with rituximab in the front line therapy a longer follow-up and randomized studies are needed.
The benefit of HDT/ASCT for refractory or relapsed DLBCL is restricted to patients with immunochemosensitive disease.
Currently, clinical and biological research is focused to improve the curability of this setting of patients, mainly young.
American Psychological Association (APA)
Gunnellini, Marco& Emili, Rita& Coaccioli, Stefano& Liberati, Anna Marina. 2012. The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-Cell Lymphoma. Advances in Hematology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453607
Modern Language Association (MLA)
Gunnellini, Marco…[et al.]. The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-Cell Lymphoma. Advances in Hematology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-453607
American Medical Association (AMA)
Gunnellini, Marco& Emili, Rita& Coaccioli, Stefano& Liberati, Anna Marina. The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-Cell Lymphoma. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453607