Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy
Joint Authors
Fan, Hui
Chen, Mei-Xia
Han, Wei-Dong
Lu, Xue-Chun
Feng, Kai-Chao
Zhang, Yajing
Zhang, Wen-Ying
Wang, Yao
Wang, Jin
Liu, Yang
Fu, Xiaobing
Zhang, Yan
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy of autologous cytokine-induced killer (CIK) cells in patients with renal cell carcinoma (RCC).
Methods.
20 patients diagnosed with TNM stage I or II RCC were randomly divided into two groups, a CIK cell treatment group and a control group.
The endpoint was progression-free survival (PFS) evaluated by Kaplan-Meier analyses.
Results.
CD3+, CD3+/CD8+, CD3+/CD4+, and CD3+/CD56+ levels increased after CIK cell culture (P<0.01).
The median PFS in CIK cell treatment group was significantly longer than that in control group (PFS, 32.2 months versus 21.6 months; log-rank, P=0.032), all patients were alive during the course of followup, and there are no statistically significant differences between two groups in OS (log-rank, P=0.214).
Grade III or greater adverse events were not observed.
Conclusions.
CIK cells treatment could prolong survival in patients with RCC after radical nephrectomy and showed acceptable curative effect with potential enhancement of cellular immune function.
This trial is registered with Clinicaltrials.gov NCT01799083.
American Psychological Association (APA)
Zhang, Yajing& Wang, Jin& Wang, Yao& Lu, Xue-Chun& Fan, Hui& Liu, Yang…[et al.]. 2013. Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-453617
Modern Language Association (MLA)
Zhang, Yajing…[et al.]. Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy. Clinical and Developmental Immunology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-453617
American Medical Association (AMA)
Zhang, Yajing& Wang, Jin& Wang, Yao& Lu, Xue-Chun& Fan, Hui& Liu, Yang…[et al.]. Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-453617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453617