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Drug Solubility : Importance and Enhancement Techniques
Joint Authors
Gajjar, Anuradha K.
Savjani, Jignasa K.
Savjani, Ketan T.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response.
Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development.
More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water.
Solubility is a major challenge for formulation scientist.
Any drug to be absorbed must be present in the form of solution at the site of absorption.
Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.
Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.
American Psychological Association (APA)
Savjani, Ketan T.& Gajjar, Anuradha K.& Savjani, Jignasa K.. 2012. Drug Solubility : Importance and Enhancement Techniques. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453620
Modern Language Association (MLA)
Savjani, Ketan T.…[et al.]. Drug Solubility : Importance and Enhancement Techniques. ISRN Pharmaceutics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-453620
American Medical Association (AMA)
Savjani, Ketan T.& Gajjar, Anuradha K.& Savjani, Jignasa K.. Drug Solubility : Importance and Enhancement Techniques. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453620