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Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati
Joint Authors
Ahmad, N.
Abdel Karim, Nagla
Haider, S.
Ying, J.
Zarzour, A.
Yasin, Z.
Sacher, R.
Siegrist, C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Thrombotic Thrombocytopenic Purpura (TTP) is a rare hematologic emergency, congenital or acquired, characterized by ischemic damage of various organs because of platelet aggregation.
It is the common name for adults with microangiopathic hemolytic anemia, thrombocytopenia, with or without neurologic or renal abnormalities, and without another etiology; children without renal failure are also described as TTP.
Plasma exchange (PE) is the main stay of treatment in combination with steroids and immunosuppressive therapies.
The monoclonal antibody against CD20 Rituximab decreases the production of antibodies from B lymphocytes and it is used for antibodies-mediated diseases including TTP.
We present our data on retrospective analysis of rituximab in treatment of TTP at University of Cincinnati in a series of 22 patients from 1997 to 2009.
Our results showed that PE with immunosuppressive therapy resulted in decreased duration of PE, relapse rate, and increased duration of remission in patients with TTP.
American Psychological Association (APA)
Abdel Karim, Nagla& Haider, S.& Siegrist, C.& Ahmad, N.& Zarzour, A.& Ying, J.…[et al.]. 2013. Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati. Advances in Hematology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-453624
Modern Language Association (MLA)
Abdel Karim, Nagla…[et al.]. Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati. Advances in Hematology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-453624
American Medical Association (AMA)
Abdel Karim, Nagla& Haider, S.& Siegrist, C.& Ahmad, N.& Zarzour, A.& Ying, J.…[et al.]. Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati. Advances in Hematology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-453624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453624