Plasticity of Cells and Ex Vivo Production of Red Blood Cells
Joint Authors
Hiroyama, Takashi
Miharada, Kenichi
Kurita, Ryo
Nakamura, Yukio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The supply of transfusable red blood cells (RBCs) is not sufficient in many countries.
If transfusable RBCs could be produced abundantly from certain resources, it would be very useful.
Our group has developed a method to produce enucleated RBCs efficiently from hematopoietic stem/progenitor cells present in umbilical cord blood.
More recently, it was reported that enucleated RBCs could be abundantly produced from human embryonic stem (ES) cells.
The common obstacle for application of these methods is that they require very high cost to produce sufficient number of RBCs that are applicable in the clinic.
If erythroid cell lines (immortalized cell lines) able to produce transfusable RBCs ex vivo were established, they would be valuable resources.
Our group developed a robust method to obtain immortalized erythroid cell lines able to produce mature RBCs.
To the best of our knowledge, this was the first paper to show the feasibility of establishing immortalized erythroid progenitor cell lines able to produce enucleated RBCs ex vivo.
This result strongly suggests that immortalized human erythroid progenitor cell lines able to produce mature RBCs ex vivo can also be established.
American Psychological Association (APA)
Hiroyama, Takashi& Miharada, Kenichi& Kurita, Ryo& Nakamura, Yukio. 2011. Plasticity of Cells and Ex Vivo Production of Red Blood Cells. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453629
Modern Language Association (MLA)
Hiroyama, Takashi…[et al.]. Plasticity of Cells and Ex Vivo Production of Red Blood Cells. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453629
American Medical Association (AMA)
Hiroyama, Takashi& Miharada, Kenichi& Kurita, Ryo& Nakamura, Yukio. Plasticity of Cells and Ex Vivo Production of Red Blood Cells. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453629