Direct Determination of ECD in ECD Kit : A Solid Sample Quantitation Method for Active Pharmaceutical Ingredient in Drug Product
Joint Authors
Hsia, Yi-Chih
Chao, Ming-Yu
Liao, Mei-Hsiu
Shen, Lie-Hang
Liu, Kung-Tien
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Technetium-99m ethyl cysteinate dimer (Tc-99m-ECD) is an essential imaging agent used in evaluating the regional cerebral blood flow in patients with cerebrovascular diseases.
Determination of active pharmaceutical ingredient, that is, L-Cysteine, N, N′-1,2-ethanediylbis-, diethyl ester, dihydrochloride (ECD) in ECD Kit is a relevant requirement for the pharmaceutical quality control in processes of mass fabrication.
We here presented a direct solid sample determination method of ECD in ECD Kit without sample dissolution to avoid the rapid degradation of ECD.
An elemental analyzer equipped with a nondispersive infrared detector and a calibration curve of coal standard was used for the quantitation of sulfur in ECD Kit.
No significant matrix effect was found.
The peak area of coal standard against the amount of sulfur was linear over the range of 0.03–0.10 mg, with a correlation coefficient (r) of 0.9993.
Method validation parameters were achieved to demonstrate the potential of this method.
American Psychological Association (APA)
Chao, Ming-Yu& Liu, Kung-Tien& Hsia, Yi-Chih& Liao, Mei-Hsiu& Shen, Lie-Hang. 2011. Direct Determination of ECD in ECD Kit : A Solid Sample Quantitation Method for Active Pharmaceutical Ingredient in Drug Product. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453674
Modern Language Association (MLA)
Chao, Ming-Yu…[et al.]. Direct Determination of ECD in ECD Kit : A Solid Sample Quantitation Method for Active Pharmaceutical Ingredient in Drug Product. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-453674
American Medical Association (AMA)
Chao, Ming-Yu& Liu, Kung-Tien& Hsia, Yi-Chih& Liao, Mei-Hsiu& Shen, Lie-Hang. Direct Determination of ECD in ECD Kit : A Solid Sample Quantitation Method for Active Pharmaceutical Ingredient in Drug Product. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453674