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The SARAH Domain of RASSF1A and Its Tumor Suppressor Function
Joint Authors
Richter, Antje M.
Steinmann, Katrin
Klagge-Ulonska, Antje
Dammann, Reinhard H.
Dittfeld, Claudia
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The Ras association domain family 1A (RASSF1A) tumor suppressor encodes a Sav-RASSF-Hpo domain (SARAH), which is an interaction domain characterized by hWW45 (dSAV) and MST1/2 (dHpo).
In our study, the interaction between RASSF1A and RASSF1C with MST1 and MST2 was demonstrated and it was shown that this interaction depends on the SARAH domain.
SARAH domain-deleted RASSF1A had a similar growth-reducing effect as full-length RASSF1A and inhibited anchorage independent growth of the lung cancer cell lines A549 significantly.
In cancer cells expressing the SARAH deleted form of RASSF1A, reduced mitotic rates (P=0.001) with abnormal metaphases (P<0.001) were observed and a significantly increased rate of apoptosis was found (P=0.006) compared to full-length RASSF1A.
Although the association with microtubules and their stabilization was unaffected, mitotic spindle formation was altered by deletion of the SARAH domain of RASSF1A.
In summary, our results suggest that the SARAH domain plays an important role in regulating the function of RASSF1A.
American Psychological Association (APA)
Dittfeld, Claudia& Richter, Antje M.& Steinmann, Katrin& Klagge-Ulonska, Antje& Dammann, Reinhard H.. 2012. The SARAH Domain of RASSF1A and Its Tumor Suppressor Function. Molecular Biology International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453724
Modern Language Association (MLA)
Dittfeld, Claudia…[et al.]. The SARAH Domain of RASSF1A and Its Tumor Suppressor Function. Molecular Biology International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-453724
American Medical Association (AMA)
Dittfeld, Claudia& Richter, Antje M.& Steinmann, Katrin& Klagge-Ulonska, Antje& Dammann, Reinhard H.. The SARAH Domain of RASSF1A and Its Tumor Suppressor Function. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453724