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Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries
Joint Authors
Bretz, Walter A.
Hauskrecht, Milos
Hart, Thomas C.
Corby, Patricia M.
Hee Ryu, Ok
Pelikan, Richard
Oliveira, Maria B.
Valko, Michal
Hoehn, Gerald T.
Source
International Journal of Dentistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The purpose of this study was to provide a univariate and multivariate analysis of genomic microbial data and salivary mass-spectrometry proteomic profiles for dental caries outcomes.
In order to determine potential useful biomarkers for dental caries, a multivariate classification analysis was employed to build predictive models capable of classifying microbial and salivary sample profiles with generalization performance.
We used high-throughput methodologies including multiplexed microbial arrays and SELDI-TOF-MS profiling to characterize the oral flora and salivary proteome in 204 children aged 1–8 years (n=118 caries-free, n=86 caries-active).
The population received little dental care and was deemed at high risk for childhood caries.
Findings of the study indicate that models incorporating both microbial and proteomic data are superior to models of only microbial or salivary data alone.
Comparison of results for the combined and independent data suggests that the combination of proteomic and microbial sources is beneficial for the classification accuracy and that combined data lead to improved predictive models for caries-active and caries-free patients.
The best predictive model had a 6% test error, >92% sensitivity, and >95% specificity.
These findings suggest that further characterization of the oral microflora and the salivary proteome associated with health and caries may provide clinically useful biomarkers to better predict future caries experience.
American Psychological Association (APA)
Hart, Thomas C.& Corby, Patricia M.& Hauskrecht, Milos& Hee Ryu, Ok& Pelikan, Richard& Valko, Michal…[et al.]. 2011. Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries. International Journal of Dentistry،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-453725
Modern Language Association (MLA)
Hart, Thomas C.…[et al.]. Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries. International Journal of Dentistry No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-453725
American Medical Association (AMA)
Hart, Thomas C.& Corby, Patricia M.& Hauskrecht, Milos& Hee Ryu, Ok& Pelikan, Richard& Valko, Michal…[et al.]. Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries. International Journal of Dentistry. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-453725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453725