Snake Venom L-Amino Acid Oxidases : Trends in Pharmacology and Biochemistry
Joint Authors
Zuliani, Juliana P.
Zanchi, Fernando B.
da Silva, Saulo Luís
Costa, Tássia R.
Grabner, Amy N.
Mendes, Mirian M.
Stábeli, Rodrigo G.
Calderon, Leonardo A.
Soares, Andreimar Martins
Rodrigues, Veridiana M.
Sobrinho, Juliana C.
Izidoro, Luiz Fernando M.
Fernandes, Carla F. C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation.
Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation.
L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity.
These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents.
This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.
American Psychological Association (APA)
Izidoro, Luiz Fernando M.& Sobrinho, Juliana C.& Mendes, Mirian M.& Costa, Tássia R.& Grabner, Amy N.& Rodrigues, Veridiana M.…[et al.]. 2014. Snake Venom L-Amino Acid Oxidases : Trends in Pharmacology and Biochemistry. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-453727
Modern Language Association (MLA)
Izidoro, Luiz Fernando M.…[et al.]. Snake Venom L-Amino Acid Oxidases : Trends in Pharmacology and Biochemistry. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-453727
American Medical Association (AMA)
Izidoro, Luiz Fernando M.& Sobrinho, Juliana C.& Mendes, Mirian M.& Costa, Tássia R.& Grabner, Amy N.& Rodrigues, Veridiana M.…[et al.]. Snake Venom L-Amino Acid Oxidases : Trends in Pharmacology and Biochemistry. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-453727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453727