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Breaking It Down : The Ubiquitin Proteasome System in Neuronal Morphogenesis
Joint Authors
Hamilton, Andrew M.
Zito, Karen
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The ubiquitin-proteasome system (UPS) is most widely known for its role in intracellular protein degradation; however, in the decades since its discovery, ubiquitination has been associated with the regulation of a wide variety of cellular processes.
The addition of ubiquitin tags, either as single moieties or as polyubiquitin chains, has been shown not only to mediate degradation by the proteasome and the lysosome, but also to modulate protein function, localization, and endocytosis.
The UPS plays a particularly important role in neurons, where local synthesis and degradation work to balance synaptic protein levels at synapses distant from the cell body.
In recent years, the UPS has come under increasing scrutiny in neurons, as elements of the UPS have been found to regulate such diverse neuronal functions as synaptic strength, homeostatic plasticity, axon guidance, and neurite outgrowth.
Here we focus on recent advances detailing the roles of the UPS in regulating the morphogenesis of axons, dendrites, and dendritic spines, with an emphasis on E3 ubiquitin ligases and their identified regulatory targets.
American Psychological Association (APA)
Hamilton, Andrew M.& Zito, Karen. 2013. Breaking It Down : The Ubiquitin Proteasome System in Neuronal Morphogenesis. Neural Plasticity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453736
Modern Language Association (MLA)
Hamilton, Andrew M.& Zito, Karen. Breaking It Down : The Ubiquitin Proteasome System in Neuronal Morphogenesis. Neural Plasticity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-453736
American Medical Association (AMA)
Hamilton, Andrew M.& Zito, Karen. Breaking It Down : The Ubiquitin Proteasome System in Neuronal Morphogenesis. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453736