MRI Findings in Neuroferritinopathy
Joint Authors
Takiyama, Yoshihisa
Ohta, Emiko
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neuroferritinopathy is a neurodegenerative disease which demonstrates brain iron accumulation caused by the mutations in the ferritin light chain gene.
On brain MRI in neuroferritinopathy, iron deposits are observed as low-intensity areas on T2WI and as signal loss on T2*WI.
On T2WI, hyperintense abnormalities reflecting tissue edema and gliosis are also seen.
Another characteristic finding is the presence of symmetrical cystic changes in the basal ganglia, which are seen in the advanced stages of this disorder.
Atrophy is sometimes noted in the cerebellar and cerebral cortices.
The variety in the MRI findings is specific to neuroferritinopathy.
Based on observations of an excessive iron content in patients with chronic neurologic disorders, such as Parkinson disease and Alzheimer disease, the presence of excess iron is therefore recognized as a major risk factor for neurodegenerative diseases.
The future development of multimodal and advanced MRI techniques is thus expected to play an important role in accurately measuring the brain iron content and thereby further elucidating the neurodegenerative process.
American Psychological Association (APA)
Ohta, Emiko& Takiyama, Yoshihisa. 2011. MRI Findings in Neuroferritinopathy. Neurology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453796
Modern Language Association (MLA)
Ohta, Emiko& Takiyama, Yoshihisa. MRI Findings in Neuroferritinopathy. Neurology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-453796
American Medical Association (AMA)
Ohta, Emiko& Takiyama, Yoshihisa. MRI Findings in Neuroferritinopathy. Neurology Research International. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453796