Factors Involved in the In Vitro Fermentability of Short Carbohydrates in Static Faecal Batch Cultures
Joint Authors
Rastall, Robert
Gibson, Glenn
de Slegte, Jaap
Mengerink, Wim
van den Heuvel, Ellen
Gietl, Eva
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In recent years, research has focused on the positive effects of prebiotics on intestinal health and gut microbiota.
The relationship between their chemical structure and their fermentation pattern by human intestinal microbiota is still not well understood.
The aim of this study was to improve understanding of this relationship and identify factors that may be used to design galactooligosaccharides that reach more distal regions than commercial prebiotics which mainly target the proximal colon.
The following factors were investigated: monomer type, linkage, substitution, and degree of polymerisation.
Total organic acid production from sugars by faecal bacteria was fitted to a model which allowed an estimate of the time when half of the maximal organic acid concentration was reached (T50) in static faecal batch cultures.
The different factors can be grouped by their effectiveness at prolonging fermentation time as follows: substitution is most effective, with methylgalactose, β-galactose-pentaacetate, D-fucose, and galactitol fermented more slowly than D-galactose.
Monomers and linkage also influence fermentation time, with L rhamnose, arabinose, melezitose, and xylose being fermented significantly slower than D-glucose (P<0.05), maltose, isomaltose, cellobiose, and gentiobiose showing that Glcα1-6Glc and Glcβ1-4Glc were utilised slowest.
Chain length had the smallest effect on fermentation time.
American Psychological Association (APA)
Gietl, Eva& Mengerink, Wim& de Slegte, Jaap& Gibson, Glenn& Rastall, Robert& van den Heuvel, Ellen. 2012. Factors Involved in the In Vitro Fermentability of Short Carbohydrates in Static Faecal Batch Cultures. International Journal of Carbohydrate Chemistry،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453826
Modern Language Association (MLA)
Gietl, Eva…[et al.]. Factors Involved in the In Vitro Fermentability of Short Carbohydrates in Static Faecal Batch Cultures. International Journal of Carbohydrate Chemistry No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-453826
American Medical Association (AMA)
Gietl, Eva& Mengerink, Wim& de Slegte, Jaap& Gibson, Glenn& Rastall, Robert& van den Heuvel, Ellen. Factors Involved in the In Vitro Fermentability of Short Carbohydrates in Static Faecal Batch Cultures. International Journal of Carbohydrate Chemistry. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-453826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453826