Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia
Joint Authors
Menon, Aparna
Shrestha, Bijayatha
Bajracharya, Dipshikha
Radhakrishnan, Raghu
Kamath, Asha
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To study the immunohistochemical expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase-2 in different histological grades of tobacco associated epithelial dysplasia and correlate the association between these proteases.
Potentially malignant oral disorders (PMODs) progressing to oral cancer are related to the severity of epithelial dysplasia.
Methods.
A retrospective immunohistochemical study was carried out on 30 clinically and histologically proven cases of leukoplakia with dysplasia and 10 cases of normal buccal mucosa using anti-MMP-2 and anti-TIMP-2 monoclonal antibodies.
Results.
Mann Whitney U test, for comparing the expression of both MMP-2 and TIMP-2 in normal mucosa with dysplasia, was highly significant (P<0.001).
Kruskal-Wallis test to compare the median score of MMP-2 and TIMP-2 in different grades of dysplasia showed statistical significance (P<0.001), and a Spearman’s correlation between MMP-2 and TIMP-2 through different grades of dysplasia and cells observed showed positive correlation.
Conclusion.
Concomitant increase in the expression of both MMP-2 and TIMP-2 suggested that the activation of MMP-2 is dependent on TIMP-2 acting as a cofactor.
Changes in TIMP-2 levels are considered important because they directly affect the level of MMP-2 activity.
American Psychological Association (APA)
Bajracharya, Dipshikha& Shrestha, Bijayatha& Kamath, Asha& Menon, Aparna& Radhakrishnan, Raghu. 2014. Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-453827
Modern Language Association (MLA)
Bajracharya, Dipshikha…[et al.]. Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-453827
American Medical Association (AMA)
Bajracharya, Dipshikha& Shrestha, Bijayatha& Kamath, Asha& Menon, Aparna& Radhakrishnan, Raghu. Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-453827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453827