A Modified Amino Acid Network Model Contains Similar and Dissimilar Weight
Joint Authors
Chen, Weiyi
An, Meiwen
Yang, Lifeng
Jiao, Xiong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
For a more detailed description of the interaction between residues, this paper proposes an amino acid network model, which contains two types of weight—similar weight and dissimilar weight.
The weight of the link is based on a self-consistent statistical contact potential between different types of amino acids.
In this model, we can get a more reasonable representation of the distance between residues.
Furthermore, with the network parameter, average shortest path length, we can get a more accurate reflection of the molecular size.
This amino acid network is a “small-world” network, and the network parameter is sensitive to the conformation change of protein.
For some disease-related proteins, the highly central residues of the amino acid network are highly correlated with the hot spots.
In the compound with the related drug, these residues either interacted directly with the drug or with the residue which is in contact with the drug.
American Psychological Association (APA)
Jiao, Xiong& Yang, Lifeng& An, Meiwen& Chen, Weiyi. 2013. A Modified Amino Acid Network Model Contains Similar and Dissimilar Weight. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453832
Modern Language Association (MLA)
Jiao, Xiong…[et al.]. A Modified Amino Acid Network Model Contains Similar and Dissimilar Weight. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-453832
American Medical Association (AMA)
Jiao, Xiong& Yang, Lifeng& An, Meiwen& Chen, Weiyi. A Modified Amino Acid Network Model Contains Similar and Dissimilar Weight. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453832