Bone Mineralization in Celiac Disease
Joint Authors
Larussa, Tiziana
Suraci, Evelina
Imeneo, Maria
Nazionale, Immacolata
Luzza, Francesco
Abenavoli, Ludovico
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Evidence indicates a well-established relationship between low bone mineral density (BMD) and celiac disease (CD), but data on the pathogenesis of bone derangement in this setting are still inconclusive.
In patients with symptomatic CD, low BMD appears to be directly related to the intestinal malabsorption.
Adherence to a strict gluten-free diet (GFD) will reverse the histological changes in the intestine and also the biochemical evidence of calcium malabsorption, resulting in rapid increase of BMD.
Nevertheless, GFD improves BMD but does not normalize it in all patients, even after the recovery of intestinal mucosa.
Other mechanisms of bone injury than calcium and vitamin D malabsorption are thought to be involved, such as proinflammatory cytokines, parathyroid function abnormalities, and misbalanced bone remodeling factors, most of all represented by the receptor activator of nuclear factor B/receptor activator of nuclear factor B-ligand/osteoprotegerin system.
By means of dual-energy X-ray absorptiometry (DXA), it is now rapid and easy to obtain semiquantitative values of BMD.
However, the question is still open about who and when submit to DXA evaluation in CD, in order to estimate risk of fractures.
Furthermore, additional information on the role of nutritional supplements and alternative therapies is needed.
American Psychological Association (APA)
Larussa, Tiziana& Suraci, Evelina& Nazionale, Immacolata& Abenavoli, Ludovico& Imeneo, Maria& Luzza, Francesco. 2012. Bone Mineralization in Celiac Disease. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453845
Modern Language Association (MLA)
Larussa, Tiziana…[et al.]. Bone Mineralization in Celiac Disease. Gastroenterology Research and Practice No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-453845
American Medical Association (AMA)
Larussa, Tiziana& Suraci, Evelina& Nazionale, Immacolata& Abenavoli, Ludovico& Imeneo, Maria& Luzza, Francesco. Bone Mineralization in Celiac Disease. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453845