Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury
Joint Authors
Zhao, Xin
Cai, Lu
Yin, Xia
Zhai, Xujie
Zheng, Yang
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ischemic preconditioning (IPC) or postconditioning (Ipost) is proved to efficiently prevent ischemia/reperfusion injuries.
Mortality of diabetic patients with acute myocardial infarction was found to be 2–6 folds higher than that of non-diabetic patients with same myocardial infarction, which may be in part due to diabetic inhibition of IPC- and Ipost-mediated protective mechanisms.
Both IPC- and Ipost-mediated myocardial protection is predominantly mediated by stimulating PI3K/Akt and associated GSK-3β pathway while diabetes-mediated pathogenic effects are found to be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway.
Therefore, this review briefly introduced the general features of IPC- and Ipost-mediated myocardial protection and the general pathogenic effects of diabetes on the myocardium.
We have collected experimental evidence that indicates the diabetic inhibition of IPC- and Ipost-mediated myocardial protection.
Increasing evidence implies that diabetic inhibition of IPC- and Ipost-mediated myocardial protection may be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway.
Therefore any strategy to activate PI3K/Akt and associated GSK-3β pathway to release the diabetic inhibition of both IPC and Ipost-mediated myocardial protection may provide the protective effect against ischemia/reperfusion injuries.
American Psychological Association (APA)
Yin, Xia& Zheng, Yang& Zhai, Xujie& Zhao, Xin& Cai, Lu. 2011. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453850
Modern Language Association (MLA)
Yin, Xia…[et al.]. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Experimental Diabetes Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-453850
American Medical Association (AMA)
Yin, Xia& Zheng, Yang& Zhai, Xujie& Zhao, Xin& Cai, Lu. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453850