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Obesity and Asthma : Physiological Perspective
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obesity induces some pertinent physiological changes which are conducive to either development of asthma or cause of poorly controlled asthma state.
Obesity related mechanical stress forces induced by abdominal and thoracic fat generate stiffening of the lungs and diaphragmatic movements to result in reduction of resting lung volumes such as functional residual capacity (FRC).
Reduced FRC is primarily an outcome of decreased expiratory reserve volume, which pushes the tidal breathing more towards smaller high resistance airways, and consequentially results in expiratory flow limitation during normal breathing in obesity.
Reduced FRC also induces plastic alteration in the small collapsible airways, which may generate smooth muscle contraction resulting in increased small airway resistance, which, however, is not picked up by spirometric lung volumes.
There is also a possibility that chronically reduced FRC may generate permanent adaptation in the very small airways; therefore, the airway calibres may not change despite weight reduction.
Obesity may also induce bronchodilator reversibility and diurnal lung functional variability.
Obesity is also associated with airway hyperresponsiveness; however, the mechanism of this is not clear.
Thus, obesity has effects on lung function that can generate respiratory distress similar to asthma and may also exaggerate the effects of preexisting asthma.
American Psychological Association (APA)
Brashier, Bill& Salvi, Sundeep. 2013. Obesity and Asthma : Physiological Perspective. Journal of Allergy،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453851
Modern Language Association (MLA)
Brashier, Bill& Salvi, Sundeep. Obesity and Asthma : Physiological Perspective. Journal of Allergy No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-453851
American Medical Association (AMA)
Brashier, Bill& Salvi, Sundeep. Obesity and Asthma : Physiological Perspective. Journal of Allergy. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453851