Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus
Joint Authors
Suematsu, Rie
Ohta, Akihide
Soejima, Sachiko
Inoue, Hisako
Tada, Yoshifumi
Nagasawa, Kohei
Koarada, Syuichi
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed to investigate phenotype of RP105(−) B cell subsets in patients with systemic lupus erythematosus (SLE).
Flow cytometry was used for phenotyping RP105-negaive B cell subsets.
Based on CD19, RP105, and CD138 expression, RP105(−) B cells consist of at least 5 subsets of late B cells, including CD19(+)RP105(int), CD19(+) RP105(−), CD19(low) RP105(−) CD138(−), CD19(low) RP105(−)CD138(int), and CD19(low) RP105(−) CD138(++) B cells.
Especially, CD19(+)RP105(int) and CD19(low) RP105(−)CD138(int) B cells are significantly larger than other RP105(−) B cell subsets in SLE.
By comparison of RP105(−) B cell subsets between patients with SLE and normal subjects, these subsets were detectable even in normal subjects, but the percentages of RP105(−) B cell subsets were significantly larger in SLE.
The phenotypic analysis of RP105(−) B cell subsets suggests dysregulation of later B cell subsets in SLE and may provide new insights into understanding regulation of B cells in human SLE.
American Psychological Association (APA)
Koarada, Syuichi& Tada, Yoshifumi& Suematsu, Rie& Soejima, Sachiko& Inoue, Hisako& Ohta, Akihide…[et al.]. 2011. Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453860
Modern Language Association (MLA)
Koarada, Syuichi…[et al.]. Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-453860
American Medical Association (AMA)
Koarada, Syuichi& Tada, Yoshifumi& Suematsu, Rie& Soejima, Sachiko& Inoue, Hisako& Ohta, Akihide…[et al.]. Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453860