Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients : Retrospective Analysis of Our Series
Joint Authors
Di Lauro, Vincenzo
Bidoli, Ettore
Veronesi, Andrea
Cecco, Sara
Quitadamo, Daniela
Torrisi, Elena
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Trastuzumab-based regimes improved clinical outcome in women with overexpressing HER2 metastatic breast cancer, mainly due to the availability of different combination therapies, clinically active and well tolerated.
In this study we retrospectively evaluated clinical activity and toxicity of trastuzuamb plus gemcitabine regimen in heavily pretreated HER2 positive metastatic breast cancer patients.
Although the observed population was heavily pretreated, the evaluated regimen was notably effective in terms of response rate, time to progression and survival, with very mild toxicity.
These data suggest that in over expressing HER2 metastatic breast cancer patients, sequential trastuzumab based chemotherapeutic regimens can achieve good response rate with prolonged TTP in responding patients, even after other target therapy such as lapatinib based combinations.
American Psychological Association (APA)
Di Lauro, Vincenzo& Torrisi, Elena& Bidoli, Ettore& Quitadamo, Daniela& Cecco, Sara& Veronesi, Andrea. 2012. Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients : Retrospective Analysis of Our Series. Journal of Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453882
Modern Language Association (MLA)
Di Lauro, Vincenzo…[et al.]. Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients : Retrospective Analysis of Our Series. Journal of Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-453882
American Medical Association (AMA)
Di Lauro, Vincenzo& Torrisi, Elena& Bidoli, Ettore& Quitadamo, Daniela& Cecco, Sara& Veronesi, Andrea. Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients : Retrospective Analysis of Our Series. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453882