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Methionine-35 of Aβ(1–42) : Importance for Oxidative Stress in Alzheimer Disease
Joint Authors
Butterfield, D. Allan
Sultana, Rukhsana
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer disease (AD) is an age-related progressive neurodegenerative disorder.
This devastating disease is characterized by the presence of senile plaques (SP), neurofibrillary tangles (NFTs), and loss of synapses.
Amyloid beta-peptide 1–42 (Aβ(1–42)) is the main component of SP and is pivotal to AD pathogenesis.
Brain of subjects with AD and arguably its earliest manifestation, mild cognitive impairment (MCI), demonstrate increased levels of oxidative stress markers.
Our laboratory combined these two aspects of AD and MCI and proposed the Aβ(1–42)-associated free radical oxidative stress hypothesis to explain oxidative stress under which the MCI and AD brain exist and the loss of synapses in both disorders.
A large number of in vitro and in vivo studies showed that Aβ causes protein oxidation, lipid peroxidation, reactive oxygen species formation, and cell death in neuronal and synaptosomal systems.
Methionine located at residue 35 of Aβ(1–42) is an important contributor to the oxidative stress associated with this neurotoxic peptide.
In this paper, we summarize studies involving Met-35 of Aβ(1–42).
Understanding the role of the single methionine residue of Aβ(1–42) may help in understanding underlying disease mechanisms in AD and MCI.
American Psychological Association (APA)
Butterfield, D. Allan& Sultana, Rukhsana. 2011. Methionine-35 of Aβ(1–42) : Importance for Oxidative Stress in Alzheimer Disease. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-453886
Modern Language Association (MLA)
Butterfield, D. Allan& Sultana, Rukhsana. Methionine-35 of Aβ(1–42) : Importance for Oxidative Stress in Alzheimer Disease. Journal of Amino Acids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-453886
American Medical Association (AMA)
Butterfield, D. Allan& Sultana, Rukhsana. Methionine-35 of Aβ(1–42) : Importance for Oxidative Stress in Alzheimer Disease. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-453886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453886