Immunological Dysregulation in Multiple Myeloma Microenvironment
Joint Authors
Vetro, Calogero
Cavalli, Maide
La Fauci, Alessia
Conticello, Concetta
Di Raimondo, Francesco
Romano, Alessandra
Parrinello, Nunziatina Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multiple Myeloma (MM) is a systemic hematologic disease due to uncontrolled proliferation of monoclonal plasma cells (PC) in bone marrow (BM).
Emerging in other solid and liquid cancers, the host immune system and the microenvironment have a pivotal role for PC growth, proliferation, survival, migration, and resistance to drugs and are responsible for some clinical manifestations of MM.
In MM, microenvironment is represented by the cellular component of a normal bone marrow together with extracellular matrix proteins, adhesion molecules, cytokines, and growth factors produced by both stromal cells and PC themselves.
All these components are able to protect PC from cytotoxic effect of chemo- and radiotherapy.
This review is focused on the role of immunome to sustain MM progression, the emerging role of myeloid derived suppressor cells, and their potential clinical implications as novel therapeutic target.
American Psychological Association (APA)
Romano, Alessandra& Conticello, Concetta& Cavalli, Maide& Vetro, Calogero& La Fauci, Alessia& Parrinello, Nunziatina Laura…[et al.]. 2014. Immunological Dysregulation in Multiple Myeloma Microenvironment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-453898
Modern Language Association (MLA)
Romano, Alessandra…[et al.]. Immunological Dysregulation in Multiple Myeloma Microenvironment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-453898
American Medical Association (AMA)
Romano, Alessandra& Conticello, Concetta& Cavalli, Maide& Vetro, Calogero& La Fauci, Alessia& Parrinello, Nunziatina Laura…[et al.]. Immunological Dysregulation in Multiple Myeloma Microenvironment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-453898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453898