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Pretreatment with Cry1Ac Protoxin Modulates the Immune Response, and Increases the Survival of Plasmodium-Infected CBACa Mice
Joint Authors
Oviedo Meza, Rodrigo
Moreno-Fierros, Leticia
Legorreta-Herrera, Martha
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Malaria is a major global health problem that kills 1-2 million people each year.
Despite exhaustive research, naturally acquired immunity is poorly understood.
Cry1A proteins are potent immunogens with adjuvant properties and are able to induce strong cellular and humoral responses.
In fact, it has been shown that administration of Cry1Ac protoxin alone or with amoebic lysates induces protection against the lethal infection caused by the protozoa Naegleria fowleri.
In this work, we studied whether Cry1Ac is able to activate the innate immune response to induce protection against Plasmodium berghei ANKA (lethal) and P.
chabaudi AS (nonlethal) parasites in CBA/Ca mice.
Treatment with Cry1Ac induced protection against both Plasmodium species in terms of reduced parasitaemia, longer survival time, modulation of pro- and anti-inflammatory cytokines, and increased levels of specific antibodies against Plasmodium.
Understanding how to boost innate immunity to Plasmodium infection should lead to immunologically based intervention strategies.
American Psychological Association (APA)
Legorreta-Herrera, Martha& Oviedo Meza, Rodrigo& Moreno-Fierros, Leticia. 2010. Pretreatment with Cry1Ac Protoxin Modulates the Immune Response, and Increases the Survival of Plasmodium-Infected CBACa Mice. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-453937
Modern Language Association (MLA)
Legorreta-Herrera, Martha…[et al.]. Pretreatment with Cry1Ac Protoxin Modulates the Immune Response, and Increases the Survival of Plasmodium-Infected CBACa Mice. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-453937
American Medical Association (AMA)
Legorreta-Herrera, Martha& Oviedo Meza, Rodrigo& Moreno-Fierros, Leticia. Pretreatment with Cry1Ac Protoxin Modulates the Immune Response, and Increases the Survival of Plasmodium-Infected CBACa Mice. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-453937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453937