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Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture
Joint Authors
Kılıç, Esma
Binzet, Gün
Külcü, Nevzat
Zeybek, Bülent
Arslan, Hakan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The stoichiometric ionization constants of N,N-dialkyl-N′-(4-substituted benzoyl) thiourea (Substitutes: H, Cl, and Br; alkyl groups: ethyl, n-propyl, n-butyl, and phenyl) derivatives have been determined potentiometrically in dioxane-water (v:v, 50:50) mixture at ionic strength of 0.1 M and 25.0±0.1°C.
The ionization constants were calculated with the BEST computer program and the formation curves using the data obtained from the potentiometric titrations.
The effects of substituents and alkyl groups on the ionization constants of the benzoyl thiourea derivatives have been investigated.
A comparison of the basicities of ethyl, n-propyl, and n-butyl thiourea derivatives (−C2H5<−C3H7<−C4H9) shows that the n-butyl group is a more powerful electron-releasing group than the other groups in 50% dioxane-50% water mixture (v:v).
So, the acidity of benzoyl thiourea derivative compounds decreases, while the length of alkyl chain increases.
The orders of pKa values for all thiourea derivatives are as expected in the light of steric, resonance and inductive effects of substituents.
Furthermore, when the basicities of halogen derivatives of the same substitution pattern are compared, orders obtained (4-Br <4-Cl <4-H) can be explained by considering the total electronic substituent effect (electron-withdrawing and electron-donating effects) except the 4-Br_Ph derivative.
American Psychological Association (APA)
Binzet, Gün& Zeybek, Bülent& Kılıç, Esma& Külcü, Nevzat& Arslan, Hakan. 2012. Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453961
Modern Language Association (MLA)
Binzet, Gün…[et al.]. Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-453961
American Medical Association (AMA)
Binzet, Gün& Zeybek, Bülent& Kılıç, Esma& Külcü, Nevzat& Arslan, Hakan. Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453961