![](/images/graphics-bg.png)
Prevention of the Musculoskeletal Complications of Hemophilia
Author
Source
Advances in Preventive Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hemophilia is an inherited disorder of clotting factor deficiencies resulting in musculoskeletal bleeding, including hemarthroses, leading to musculoskeletal complications.
The articular problems of hemophiliac patients begin in infancy.
These include: recurrent hemarthroses, chronic synovitis, flexion deformities, hypertrophy of the growth epiphyses, damage to the articular cartilage, and hemophilic arthropathy.
The most commonly affected joints are the ankle, the knee, and the elbow.
Hematologic prophylactic treatment from ages 2 to 18 years could avoid the development of hemophilic arthropathy if the concentration of the patient's deficient factor is prevented from falling below 1% of normal.
Hemarthroses can be prevented by the administration of clotting factor concentrates (prophylaxis).
However, high costs and the need for venous access devices in younger children continue to complicate recommendations for universal prophylaxis.
Prevention of joint arthropathy needs to focus on prevention of hemarthroses through prophylaxis, identifying early joint disease through the optimal use of cost-effective imaging modalities and the validation of serological markers of joint arthropathy.
Screening for effects on bone health and optimal management of pain to improve quality of life are, likewise, important issues.
Major hemarthrosis and chronic hemophilic synovitis should be treated aggressively to prevent hemophilic arthropathy.
American Psychological Association (APA)
Rodriguez-Merchan, E. C.. 2012. Prevention of the Musculoskeletal Complications of Hemophilia. Advances in Preventive Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453965
Modern Language Association (MLA)
Rodriguez-Merchan, E. C.. Prevention of the Musculoskeletal Complications of Hemophilia. Advances in Preventive Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-453965
American Medical Association (AMA)
Rodriguez-Merchan, E. C.. Prevention of the Musculoskeletal Complications of Hemophilia. Advances in Preventive Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453965