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Cellular Responses to Cisplatin-Induced DNA Damage
Joint Authors
Basu, Alakananda
Krishnamurthy, Soumya
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-08
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors.
It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis.
How cells respond to cisplatin-induced DNA damage plays a critical role in deciding cisplatin sensitivity.
Cisplatin-induced DNA damage activates various signaling pathways to prevent or promote cell death.
This paper summarizes our current understandings regarding the mechanisms by which cisplatin induces cell death and the bases of cisplatin resistance.
We have discussed various steps, including the entry of cisplatin inside cells, DNA repair, drug detoxification, DNA damage response, and regulation of cisplatin-induced apoptosis by protein kinases.
An understanding of how various signaling pathways regulate cisplatin-induced cell death should aid in the development of more effective therapeutic strategies for the treatment of cancer.
American Psychological Association (APA)
Basu, Alakananda& Krishnamurthy, Soumya. 2010. Cellular Responses to Cisplatin-Induced DNA Damage. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-453975
Modern Language Association (MLA)
Basu, Alakananda& Krishnamurthy, Soumya. Cellular Responses to Cisplatin-Induced DNA Damage. Journal of Nucleic Acids No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-453975
American Medical Association (AMA)
Basu, Alakananda& Krishnamurthy, Soumya. Cellular Responses to Cisplatin-Induced DNA Damage. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-453975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453975