Blockade of Alternative Complement Pathway in Dense Deposit Disease
Joint Authors
Frémeaux-Bacchi, Véronique
Fila, Marc
Perrier-Cornet, Emilia
Peuchmaur, Michel
Berthe-Aucejo, Aurore
Deschênes, Georges
Sacquépée, Mathieu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Steroid therapy, plasma exchange, and rituximab failed to improve proteinuria and hypertension despite a normalization of the circulating sC5b9 complex.
Eculizumab, a monoclonal antibody directed against C5, was used to block the terminal product of the complement cascade.
The dose was adapted to achieve a CH50 below 10%, but proteinuria and blood pressure were not improved after 3 months of treatment.
American Psychological Association (APA)
Berthe-Aucejo, Aurore& Sacquépée, Mathieu& Fila, Marc& Peuchmaur, Michel& Perrier-Cornet, Emilia& Frémeaux-Bacchi, Véronique…[et al.]. 2014. Blockade of Alternative Complement Pathway in Dense Deposit Disease. Case Reports in Nephrology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-453993
Modern Language Association (MLA)
Berthe-Aucejo, Aurore…[et al.]. Blockade of Alternative Complement Pathway in Dense Deposit Disease. Case Reports in Nephrology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-453993
American Medical Association (AMA)
Berthe-Aucejo, Aurore& Sacquépée, Mathieu& Fila, Marc& Peuchmaur, Michel& Perrier-Cornet, Emilia& Frémeaux-Bacchi, Véronique…[et al.]. Blockade of Alternative Complement Pathway in Dense Deposit Disease. Case Reports in Nephrology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-453993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453993