Synthesis of N-(6-(4-(Piperazin-1-yl)‎phenoxy)‎pyridin-3-yl)‎benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

Abstract EN

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus.

High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder.

Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus.

They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded.

Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.