Oxaliplatin-Induced Neuropathy in Colorectal Cancer
Joint Authors
Wells, Keith
Weickhardt, Andrew
Messersmith, Wells
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxaliplatin use in palliative and adjuvant treatment of colon cancer is frequently limited by cumulative neurotoxicity, leading to reduced quality of life and decreased dose.
The mechanism of this neurotoxicity is unclear, but may relate to neuronal voltage-gated sodium channels involving calcium chelation by a metabolite of the drug.
Various preventative measures have been tested to reduce the incidence of neurotoxicity, including calcium and magnesium infusions, dose interruption of the drug, and prophylactic neuromodulatory agents.
Despite the promising efficacy of these measures, they are not universally accepted.
Less is known about the best way to treat established neurotoxicity, which is permanent in some patients, although venlafaxine has shown promise in small clinical trials.
This paper analyzes the extent, cause and risk factors for neuropathy, and the potential preventative and therapeutic treatments for oxaliplatin-induced neuropathy.
American Psychological Association (APA)
Weickhardt, Andrew& Wells, Keith& Messersmith, Wells. 2011. Oxaliplatin-Induced Neuropathy in Colorectal Cancer. Journal of Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453996
Modern Language Association (MLA)
Weickhardt, Andrew…[et al.]. Oxaliplatin-Induced Neuropathy in Colorectal Cancer. Journal of Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-453996
American Medical Association (AMA)
Weickhardt, Andrew& Wells, Keith& Messersmith, Wells. Oxaliplatin-Induced Neuropathy in Colorectal Cancer. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453996