Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline
Joint Authors
Debrah, Alexander Yaw
Marfo-Debrekyei, Yeboah
Pfarr, Kenneth
Mand, Sabine
Adjei, Ohene
Klarmann, Ute
Albers, Anna
Batsa, Linda
Specht, Sabine
Hoerauf, Achim
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis.
Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection.
Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects.
In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo.
Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS).
Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly.
At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss.
In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W.
bancrofti.
American Psychological Association (APA)
Debrah, Alexander Yaw& Mand, Sabine& Marfo-Debrekyei, Yeboah& Batsa, Linda& Albers, Anna& Specht, Sabine…[et al.]. 2011. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453997
Modern Language Association (MLA)
Debrah, Alexander Yaw…[et al.]. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. Journal of Parasitology Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-453997
American Medical Association (AMA)
Debrah, Alexander Yaw& Mand, Sabine& Marfo-Debrekyei, Yeboah& Batsa, Linda& Albers, Anna& Specht, Sabine…[et al.]. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453997