The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation
Joint Authors
Yamaguchi, Akihiko
Sakuma, Kunihiro
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This paper summarizes the various effects of neurotrophins in skeletal muscle and how these proteins act as potential regulators of the maintenance, function, and regeneration of skeletal muscle fibers.
Increasing evidence suggests that this family of neurotrophic factors influence not only the survival and function of innervating motoneurons but also the development and differentiation of myoblasts and muscle fibers.
Muscle contractions (e.g., exercise) produce BDNF mRNA and protein in skeletal muscle, and the BDNF seems to play a role in enhancing glucose metabolism and may act for myokine to improve various brain disorders (e.g., Alzheimer's disease and major depression).
In adults with neuromuscular disorders, variations in neurotrophin expression are found, and the role of neurotrophins under such conditions is beginning to be elucidated.
This paper provides a basis for a better understanding of the role of these factors under such pathological conditions and for treatment of human neuromuscular disease.
American Psychological Association (APA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. 2011. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454009
Modern Language Association (MLA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-454009
American Medical Association (AMA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454009