Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Joint Authors

Strand, Elin
Seifert, Reinhard
Bohov, Pavol
Berge, Rolf Kristian
Nilsen, Dennis W. T.
Ringdal Pedersen, Eva
Nygård, Ottar Kjell
Ueland, Per Magne
Wilberg, Eirik Rebnord
Dierkes, Jutta
Borgeraas, Heidi

Source

Cardiology Research and Practice

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-12-31

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Background.

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase.

A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs).

We sought to examine if an association between plasma ADMA and risk of acute myocardial infarction (AMI) was modified by serum n-3 PUFA status.

Methods.

The cohort included 1364 patients who underwent coronary angiography for suspected coronary artery disease in 2000-2001.

Fatal and nonfatal AMI events were registered until December 31, 2006.

Risk associations with AMI were estimated across ADMA quartiles (linear trend) and the upper decile.

Results.

No association between concentration of any n-3 PUFA and ADMA was observed.

Only ADMA levels in upper decile were significantly associated with AMI with a multivariate adjusted hazard ratio (HR) (95% confidence interval) versus the rest of the population of 2.11 (1.34, 3.32).

The association was strengthened among patients with below median levels of α-linolenic acid (ALA) (HR 3.12 (1.64, 5.93)), but was only influenced by longer chain n-3 PUFA after additional adjustments for HbA1c, estimated glomerular filtration rate, and hypercholesterolemia.

Conclusions.

The association of ADMA with risk of AMI is influenced by serum n-3 PUFA and particularly ALA.

American Psychological Association (APA)

Borgeraas, Heidi& Strand, Elin& Ringdal Pedersen, Eva& Dierkes, Jutta& Ueland, Per Magne& Seifert, Reinhard…[et al.]. 2012. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454016

Modern Language Association (MLA)

Borgeraas, Heidi…[et al.]. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-454016

American Medical Association (AMA)

Borgeraas, Heidi& Strand, Elin& Ringdal Pedersen, Eva& Dierkes, Jutta& Ueland, Per Magne& Seifert, Reinhard…[et al.]. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454016

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-454016