Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease
Joint Authors
Strand, Elin
Seifert, Reinhard
Bohov, Pavol
Berge, Rolf Kristian
Nilsen, Dennis W. T.
Ringdal Pedersen, Eva
Nygård, Ottar Kjell
Ueland, Per Magne
Wilberg, Eirik Rebnord
Dierkes, Jutta
Borgeraas, Heidi
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase.
A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs).
We sought to examine if an association between plasma ADMA and risk of acute myocardial infarction (AMI) was modified by serum n-3 PUFA status.
Methods.
The cohort included 1364 patients who underwent coronary angiography for suspected coronary artery disease in 2000-2001.
Fatal and nonfatal AMI events were registered until December 31, 2006.
Risk associations with AMI were estimated across ADMA quartiles (linear trend) and the upper decile.
Results.
No association between concentration of any n-3 PUFA and ADMA was observed.
Only ADMA levels in upper decile were significantly associated with AMI with a multivariate adjusted hazard ratio (HR) (95% confidence interval) versus the rest of the population of 2.11 (1.34, 3.32).
The association was strengthened among patients with below median levels of α-linolenic acid (ALA) (HR 3.12 (1.64, 5.93)), but was only influenced by longer chain n-3 PUFA after additional adjustments for HbA1c, estimated glomerular filtration rate, and hypercholesterolemia.
Conclusions.
The association of ADMA with risk of AMI is influenced by serum n-3 PUFA and particularly ALA.
American Psychological Association (APA)
Borgeraas, Heidi& Strand, Elin& Ringdal Pedersen, Eva& Dierkes, Jutta& Ueland, Per Magne& Seifert, Reinhard…[et al.]. 2012. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454016
Modern Language Association (MLA)
Borgeraas, Heidi…[et al.]. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-454016
American Medical Association (AMA)
Borgeraas, Heidi& Strand, Elin& Ringdal Pedersen, Eva& Dierkes, Jutta& Ueland, Per Magne& Seifert, Reinhard…[et al.]. Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454016