![](/images/graphics-bg.png)
Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis
Joint Authors
Chung, Lorinda
Fiorentino, David F.
Arefiev, Kait
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Systemic sclerosis is a connective tissue disease characterized by fibrosis of the skin, internal organs, and widespread vasculopathy.
Raynaud's phenomenon and digital ulcers are vascular manifestations of this disease and cause significant morbidity.
Current treatments are only moderately effective in reducing the severity of Raynaud's in a portion of patients and typically do not lead to substantial benefit in terms of the healing or prevention of digital ulcers.
Several studies have evaluated the efficacy of targeting the vasoconstrictor endothelin-1 for the treatment of systemic sclerosis-associated vascular disease.
The purpose of this paper is to summarize the published studies and case reports evaluating the efficacy of endothelin receptor antagonists in the treatment of Raynaud's phenomenon and digital ulcers associated with systemic sclerosis.
American Psychological Association (APA)
Arefiev, Kait& Fiorentino, David F.& Chung, Lorinda. 2011. Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454025
Modern Language Association (MLA)
Arefiev, Kait…[et al.]. Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454025
American Medical Association (AMA)
Arefiev, Kait& Fiorentino, David F.& Chung, Lorinda. Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454025