Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis
Joint Authors
Kim, Sun-Young
Kim, Hyung-Keun
Yeom, Ju-Ok
Cho, Young-Seok
Kim, Sung-Soo
Chae, Hiun-Suk
Cho, Hyunjung
Jang, Eun-Chul
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Aim.
Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections.
We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy.
Methods.
Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H.
pylori infection and the degree of endoscopic and histologic gastritis were investigated.
In all subjects, serum prohepcidin and iron parameters were evaluated.
Results.
No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity.
Serum prohepcidin levels were not significantly different between the H.
pylori-positive group and the H.
pylori-negative group.
Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H.
pylori infection.
Conclusion.
Serum prohepcidin levels were not altered by H.
pylori infection.
Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H.
pylori infection.
It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells.
Further investigations with a larger number of patients are necessary to substantiate this point.
American Psychological Association (APA)
Kim, Hyung-Keun& Jang, Eun-Chul& Yeom, Ju-Ok& Kim, Sun-Young& Cho, Hyunjung& Kim, Sung-Soo…[et al.]. 2013. Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454029
Modern Language Association (MLA)
Kim, Hyung-Keun…[et al.]. Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis. Gastroenterology Research and Practice No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-454029
American Medical Association (AMA)
Kim, Hyung-Keun& Jang, Eun-Chul& Yeom, Ju-Ok& Kim, Sun-Young& Cho, Hyunjung& Kim, Sung-Soo…[et al.]. Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454029