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Eicosanoids in the Innate Immune Response : TLR and Non-TLR Routes
Joint Authors
Municio, Cristina
Valera, Isela
Rodríguez, Mario
Fernández, Nieves
Blanco, Lydia
Padrón, Francisco
Alvarez, Yolanda
Hugo, Etzel
Crespo, Mariano Sánchez
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism.
Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE2, PGD2, and several cytokines including a robust IL-10 response.
Zymosan activated κB-binding activity, but inhibition of NF-κB was associated with enhanced IL-10 production.
In contrast, treatments acting on CREB (CRE binding protein), including PGE2, showed a direct correlation between CREB activation and IL-10 production.
Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE2, thus unraveling a functional cooperation between eicosanoid production and cytokine production.
American Psychological Association (APA)
Alvarez, Yolanda& Valera, Isela& Municio, Cristina& Hugo, Etzel& Padrón, Francisco& Blanco, Lydia…[et al.]. 2010. Eicosanoids in the Innate Immune Response : TLR and Non-TLR Routes. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-454046
Modern Language Association (MLA)
Alvarez, Yolanda…[et al.]. Eicosanoids in the Innate Immune Response : TLR and Non-TLR Routes. Mediators of Inflammation No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-454046
American Medical Association (AMA)
Alvarez, Yolanda& Valera, Isela& Municio, Cristina& Hugo, Etzel& Padrón, Francisco& Blanco, Lydia…[et al.]. Eicosanoids in the Innate Immune Response : TLR and Non-TLR Routes. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-454046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454046