Quantitatively Controlled Fabrication of Uniaxially Aligned Nanofibrous Scaffold for Cell Adhesion
Joint Authors
Hong, Jung Woo
Shin, Jennifer Hyunjong
Park, Suk Hee
Yang, Dong-Yol
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
In light of tissue engineering, development of a functional and controllable scaffold which can promote cell proliferation and differentiation is crucial.
In this study, we introduce a controllable collection method of the electrospinning process for regularly-distributed and uniaxially oriented nanofiber scaffold and evaluate the effects of aligned nanofiber density on adhesion of dermal fibroblasts.
The suggested spinning collector features an inclined void gap, which allows easy transfer of uniformly aligned fibers onto other surfaces.
By undergoing multiple transfers, the density of the nanofibers can be quantitatively controlled.
The resultant polycaprolactone (PCL) nanofibers had well-defined nanotopography in a 400–600 nm range.
Human dermal fibroblasts were seeded on aligned nanofiber scaffolds of different densities achieved by varying the number of transfers.
Cell morphology and actin stress fiber formation was accessed after seven days.
The experimental results indicate that the contact guidance of the cells along the fiber alignment can be more activated with more than one guidance feature on a cell; that is, the high density of fiber is attained in so much that fiber spacing gets below the cell size.
American Psychological Association (APA)
Park, Suk Hee& Hong, Jung Woo& Shin, Jennifer Hyunjong& Yang, Dong-Yol. 2011. Quantitatively Controlled Fabrication of Uniaxially Aligned Nanofibrous Scaffold for Cell Adhesion. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454052
Modern Language Association (MLA)
Park, Suk Hee…[et al.]. Quantitatively Controlled Fabrication of Uniaxially Aligned Nanofibrous Scaffold for Cell Adhesion. Journal of Nanomaterials No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-454052
American Medical Association (AMA)
Park, Suk Hee& Hong, Jung Woo& Shin, Jennifer Hyunjong& Yang, Dong-Yol. Quantitatively Controlled Fabrication of Uniaxially Aligned Nanofibrous Scaffold for Cell Adhesion. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454052