Regulation of Regenerative Periodontal Healing by NAMPT
Joint Authors
Jepsen, Søren
Jäger, Andreas
Deschner, James
Nokhbehsaim, Marjan
Keser, Sema
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues.
Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases.
Recently, increased levels of NAMPT have also been found in patients with periodontitis, irrespective of the presence of obesity.
This in vitro study sought to examine the effects of NAMPT on the regenerative capacity of human periodontal ligament (PDL) cells and, thereby, periodontal healing.
PDL cells treated with enamel matrix derivative (EMD), which was used to mimic regenerative healing conditions in vitro, were grown in the presence and absence of NAMPT for up to 14 d.
EMD stimulated significantly (P<0.05) the expression of growth factors and their receptors, matrix molecules, osteogenesis-associated factors, and wound closure and calcium accumulation.
In the presence of NAMPT, all these stimulatory effects were significantly (P<0.05) reduced.
In conclusion, the beneficial effects of EMD on a number of PDL cell functions critical for periodontal regeneration are counteracted by NAMPT.
Enhanced levels of NAMPT, as found in obesity and periodontal inflammation, may compromise the regenerative capacity of PDL cells and, thereby, periodontal healing in the presence of EMD.
American Psychological Association (APA)
Nokhbehsaim, Marjan& Keser, Sema& Jäger, Andreas& Jepsen, Søren& Deschner, James. 2013. Regulation of Regenerative Periodontal Healing by NAMPT. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-454085
Modern Language Association (MLA)
Nokhbehsaim, Marjan…[et al.]. Regulation of Regenerative Periodontal Healing by NAMPT. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-454085
American Medical Association (AMA)
Nokhbehsaim, Marjan& Keser, Sema& Jäger, Andreas& Jepsen, Søren& Deschner, James. Regulation of Regenerative Periodontal Healing by NAMPT. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-454085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454085